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The Use of Photochemical Probes for Studies of Structure and Function of Purified Acetylcholine Receptor Preparations *
Author(s) -
Raftery Michael A.,
Witzemann Veil,
Blanchard Steven G.
Publication year - 1980
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1980.tb22117.x
Subject(s) - chemical technology , chemical biology , library science , chemistry , environmental ethics , engineering , computer science , philosophy , biochemistry , biochemical engineering
In the studies reported here, we have made use of a variety of photosensitive derivatives for studies of the subunit structure of Torpedo californica in its native membrane environment, the detection of cholinergic agonist−induced subunit interactions, the location of the binding site(s) for a cholinergic antagonist, and the identification of a polypeptide that can be labeled with a local anesthetic analo