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ION PATHWAYS IN PROTEINS OF THE SARCOPLASMIC RETICULUM *
Author(s) -
MacLennan David H.,
Reithmeier Reinhart A. F.,
Shoshan Varda,
Campbell Kevin P.,
LeBel Denis,
Herrmann Tom R.,
Shamoo Adil E.
Publication year - 1980
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1980.tb15392.x
Subject(s) - library science , best practice , medicine , media studies , gerontology , political science , sociology , law , computer science
In summary, we have begun to characterize three different ion pathways in the sarcoplasmic reticulum. Ca2+-ionophoric activity has been traced to a 13,000-dalton CNBr fragment localized at the amino terminus of the ATPase molecule... The pathway involved in Ca2+ release can be distinguished from the pathway involved in Ca2+ uptake by its insensitivity to quercetin. An anion pathway is sensitive to DIDS and appears to be localized in the ATPase molecule