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MUSCULAR DYSTROPHY IN THE MOUSE: NEUROMUSCULAR TRANSMISSION AND THE CONCEPT OF FUNCTIONAL DENERVATION *
Author(s) -
Harris J. B.,
Ribchester R. R.
Publication year - 1979
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1979.tb56522.x
Subject(s) - newcastle upon tyne , muscular dystrophy , medicine , general hospital , annals , family medicine , classics , history , art history
The results of recent investigations by ourselves and others indicate that no form of denervation exists to any remarkable degree in dystrophic mouse skeletal muscles. This conclusion is based on the following information: Dystrophic nerve terminals liberate normal amounts of transmitter both spontaneously and during impulse-mediated activity. The characteristics of the release process, the size of the available store of transmitter, and the probability of release of transmitter in response to the invasion of an action potential appear to be normal. The sensitivity of the postsynaptic membrane to the transmitter is normal. Action potential generation in response to both direct and indirect excitation is normal. There is no unequivocal pharmacologic evidence of denervation in dystrophic skeletal muscle, even though dystrophic muscle fibers respond to surgical denervation in a normal fashion. Nerve terminal sprouting is extensive, but there is no evidence of collateral reinnervation.