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INTRACELLULAR AND EXTRACELLULAR CALCIUM IONS IN TRANSMITTER RELEASE AT THE NEUROMUSCULAR SYNAPSE *
Author(s) -
Rahamimoff R.,
Erulkar S.D.,
LevTov A.,
Meiri Halina
Publication year - 1978
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1978.tb41983.x
Subject(s) - calcium , extracellular , synapse , neuromuscular junction , chemistry , biophysics , intracellular , t type calcium channel , plasma membrane ca2+ atpase , long term potentiation , calcium in biology , neuroscience , voltage dependent calcium channel , biochemistry , biology , atpase , receptor , enzyme , organic chemistry
The theme of this presentation has been to show that the control of transmitter release at the neuromuscular synapse is achieved by extracellular and intracellular calcium. For the fast information transfer represented by the end-plate potential, the electrochemical gradient for calcium across the presynaptic membrane and the associated calcium conductance seem to play the primary role. For slower processes such as tetanic and posttetanic potentiation, the combined effect of both sources for calcium determine the amount of transmitter liberated.