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CLINICAL PHARMACOLOGY OF NARCOTIC ANTAGONISTS *
Author(s) -
O'Brien Charles P.,
Greenstein Robert,
Ternes Joseph,
Woody George E.
Publication year - 1978
Publication title -
annals of the new york academy of sciences
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1978.tb16779.x
Subject(s) - administration (probate law) , medicine , veterans affairs , george (robot) , general hospital , psychiatry , family medicine , history , political science , law , art history
Both naloxone and naltrexone are effective narcotic antagonists with minimal agonistic effects and a wide margin of safety. Naloxone is useful in the treatment of narcotic overdose and it is helpful in the quantification of physical dependence. Naltrexone is pharmacologically successful as an orally effective, long-acting antagonist but its clinical usefulness in the prevention of relapse is still being determined.