Premium
BASE SPECIFICITY IN THE INHIBITION OF ONCORNAVIRUS REVERSE TRANSCRIPTASE AND CELLULAR NUCLEIC ACID POLYMERASES BY ANTITUMOR DRUGS *
Author(s) -
Sethi V. Sagar
Publication year - 1977
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1977.tb21984.x
Subject(s) - reverse transcriptase , anthem , citation , library science , biology , genetics , computer science , history , rna , art history , gene
Adriamycin, daunomycin, acridylmethanesulfonanilide, and alkoxybenzophenanthridine alkaloids (coralyne acetosulfate, fagaronine chloride, and nitidine chloride) inhibit template-directed nucleic acid polymerizing enzyme activities like reverse transcriptase, DNA polymerase, and RNA polymerase. Enzyme reactions with poly(dA-dT), poly(rA)-oligo(dT) and poly(dA)-oligo(dT) are more strongly inhibited by the drugs than those with poly(dC)-poly(dG) and poly(rC)-oligo(dG). These results suggest that the antitumor drugs inhibit nucleic acid polymerases by a specific interaction with A:T base pairs of the templates.