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THE EFFECT OF l‐β‐D‐RIBOFURANOSYL‐1,2,4‐TRIAZOLE‐3‐CARBOXAMIDE ON ACUTE VIRAL HEPATITIS
Author(s) -
AyrosaGalvão Paulo A,
Castro Ivan O
Publication year - 1977
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1977.tb21961.x
Subject(s) - ribavirin , bilirubin , medicine , placebo , gastroenterology , carboxamide , hepatitis , serum bilirubin , pharmacology , hepatitis c virus , virology , chemistry , virus , biochemistry , pathology , alternative medicine
We studied the effect of 1-beta-ribofuranosyl-1,2,4-traizole-3-carboxamide (ribavirin) on 66 patients with acute viral hepatitis, by a double-blind study. Thirty-three of these patients received the active drug and the other 33 received a placebo. The effect of ribavirin was evaluated by the clinical picture and by the changes in both direct and total serum bilirubin and in the activity of serum glutamic-pyruvic and glutamic-oxaloacetic transaminases. There was a significant decrease in serum bilirubin, SGOT, and SGPT from the 5th to 10th day of treatment in the ribavirin group. In the placebo group such a decrease was observed but was not statistically significant.