Premium
EFFECT OF RIBAVIRIN ON TYPE 2 HERPESVIRUS HOMINIS (HVH/2) IN VITRO AND IN VIVO
Author(s) -
Allen L. B.,
Wolf S. M.,
Hintz C. J.,
Huffman J. H.,
Sidwell R. W.
Publication year - 1977
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1977.tb21957.x
Subject(s) - nucleic acid , basic research , library science , chemistry , biochemistry , computer science
Ribavirin was found to inhibit five strains of HVH/2 tested in KB cells with the M1C range being 10-100 microgram/ml. In a mouse tail animal model, it effectively reduced HVH/2-induced lesions particularly at the peak lesion periods. Ribavirin was remarkably effective when intravaginal treatment was initiated late in the infection, which suggests that it may have potential for treatment of human cutaneous infections.