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ANTIBODY‐DEPENDENT CELLULAR CYTOTOXICITY AND B‐ AND T‐CELL ACTIVITY IN THE PERIPHERAL BLOOD OF MYASTHENIA GRAVIS PATIENTS *
Author(s) -
Kalden Joachim R.,
Lohmann Ernst,
Peter Hans H.,
Hilger Christa
Publication year - 1976
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1976.tb47703.x
Subject(s) - myasthenia gravis , antibody , cytotoxicity , peripheral blood , immunology , medicine , chemistry , in vitro , biochemistry
Antibody-dependent cellular cytotoxicity (ADCC) was found to be significantly decreased in whole blood as well as in purified lymphocyte preparations from myasthenia gravis patients. Decreased ADCC was found not to correlate with the clinical classification nor with the therapy regimen, including immunosuppressive agents. PHA, Con A, and PPD responsiveness of peripheral blood lymphocytes was normal. Likewise no significant decrease was observed in the T-and B-cell distribution in the peripheral blood.