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IMMUNOPEROXIDASE LOCALIZATION OF ALPHA BUNGAROTOXIN: A NEW APPROACH TO MYASTHENIA GRAVIS *
Author(s) -
Bender Adam N.,
Ringel Steven P.,
Engel W. King,
Vogel Zvi,
Daniels Mathew P.
Publication year - 1976
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1976.tb47673.x
Subject(s) - myasthenia gravis , immunoperoxidase , bungarotoxin , alpha (finance) , medicine , chemistry , acetylcholine receptor , immunology , antibody , receptor , surgery , construct validity , patient satisfaction , monoclonal antibody
The IPBT method has made it possible to precisely visualize the AChR. Normal distribution of AChR is at the peaks of the postjunctional folds of the muscle sarcolemmal membrane with a small amount present on the axonal tip as well. Denervated muscle fibers have extrajunctional AChR. In MG, there are also denervated-appearing fibers but these do not have extrajuctional AChR with the IPBT stain. To explain this, we have been able to demonstrate a serum factor capable of blocking the binding of alpha-BuTx to the AChR and have shown for the first time that this factor is capable of acting at the neuromuscular junction itself. This blocking factor may play a major role in causing the weakness of MG.