Premium
EXPERIENCE WITH A DUTCH KVEIM SUSPENSION IN MEN AND GUINEA PIGS *
Author(s) -
Kooy R.,
Ruitenberg E. J.,
Sirks J. L.,
Stam J.,
Meyer S.
Publication year - 1976
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1976.tb47086.x
Subject(s) - sarcoidosis , reactogenicity , spleen , medicine , antigen , immunology , guinea pig , dermatology , immunogenicity
A Kveim antigen was prepared according to the Chase-Siltzbach method from the spleen of a patient with sarcoidosis. This antigen was tested in a number of patients with sarcoidosis or possible sarcoidosis and also in a number of non-sarcoid patients. Several lots prepared from this spleen were compared, yielding differences in reactogenicity. Maybe this can be explained by heterogeneity of the spleen. An animal model (the BCG-presensitized guinea pig) is presented that may be applicable for a preclinical evaluation of lots of Kveim antigen.