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FAMILIAL SARCOIDOSIS WITH MULTIPLE OCCURRENCES IN ELEVEN FAMILIES: A POSSIBLE MECHANISM OF INHERITANCE
Author(s) -
Headings Verle E.,
Weston Denise,
Young Roscoe C.,
Hackney Robert L.
Publication year - 1976
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1976.tb47049.x
Subject(s) - medicine , gerontology , family medicine , library science , computer science
Among 80 Black patients with sarcoidosis, 11 families were identified as containing multiple cases. Monogenic modes of inheritance were reasonably excluded by informal inspection of pedigree patterns and by poor fit of corrected ratios within sibships to the expected ratio for all sibships at risk. The observed familial distribution conforms in several respects to properties that are descriptive of multigenic traits. Additionally, heritability based only on female probands was estimated to be between 60% and 70%. A larger sample size should permit analysis of additional multigenic properties.