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MACROPHAGE REACTIVITY IN SKIN WINDOW OF SARCOIDOSIS PATIENTS
Author(s) -
Kohout Josef
Publication year - 1976
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1976.tb47030.x
Subject(s) - sarcoidosis , citation , medicine , humanities , philosophy , library science , dermatology , computer science
We investigated 582 cases of sarcoidosis by the skin-window (Rebuck) method. The number of macrophages appearing in skin windows was significantly increased in 432 patients with sarcoidosis in the active phase. Further, increased numbers of macrophages in the windows were found in patients with a positive Kveim-Siltzbach test, high immunoglobulin levels, increased B lymphocytes, and decreased T lymphocytes. Passive transfer of delayed-type hypersensitivity was weaker and shorter in sarcoidosis patients with increased presence of macrophages than in healthy controls. A close correlation between high macrophage reactivity and the other sepcific immunological factors in sarcoidosis is suggested.