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CHARACTERIZATION OF PERIPHERAL BLOOD LYMPHOCYTES IN SARCOIDOSIS
Author(s) -
Hedfors Eva
Publication year - 1976
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1976.tb47020.x
Subject(s) - immunology , antigen , sarcoidosis , cytotoxicity , basal (medicine) , cell , biology , dna synthesis , stimulation , t cell , dna , medicine , in vitro , immune system , pathology , endocrinology , genetics , insulin
In the basal state, patients with sarcoidosis have reduced numbers of circulating T lymphocytes and a normal number of circulating B lymphocytes. The lymphocytes show impaired DNA synthesis in response to several mitogens and antigens and impaired K-cell cytotoxicity. Circulating atypical cells of lymphocytic origin are present belonging to both T- and B-cell lineages. After work (with mobilization of lymphocytes) the T-cell deficiency is further accentuated compared with normals. Moreover, after work a deficiency in the number of circulating B cells is also encountered. The atypical cells do not increase. Compared with normals the impaired K-cell cytotoxicity and lower levels of DNA synthesis also persist. It is suggested that the deviations found in sarcoidosis are consequences of a disease process affecting the lymphoid tissues and successively replacing the normal structures. The presence in vivo of DNA-synthesizing circulating lymphocytes may indicate a persistent antigenic stimulation.