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DISCUSSION PAPER: LOSS OF CELLULAR ANTIGENS DURING MALIGNANT TRANSFORMATION *
Author(s) -
Rose Noel R.,
Bartholomew William R.
Publication year - 1976
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1976.tb41650.x
Subject(s) - transformation (genetics) , antigen , malignant transformation , chemistry , microbiology and biotechnology , cancer research , immunology , computational biology , biology , biochemistry , gene
Normal human diploid cells, such as WE-38, transformed by an oncogenic virus, SV40, are greatly depleted of a cathodal esterase isozyme using both immunological and enzymatic criteria. This cathodal esterase is primate-specific and associated with lysosomes of many different tissue cells. It provides a clear example of antigenic loss associated with malignant change.