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MACROPHAGE MEDIATED TUMOR CELL CYTOTOXICITY *
Author(s) -
Kaplan Alan M.,
Morahan Page S.
Publication year - 1976
Publication title -
annals of the new york academy of sciences
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1976.tb41642.x
Subject(s) - macrophage , trypan blue , peritoneal cavity , cytotoxicity , infiltration (hvac) , cancer research , effector , chemistry , in vitro , peritoneum , pathology , immunology , biology , medicine , biochemistry , physics , anatomy , thermodynamics
The following evidence from our research has implicated the macrophage as an important effector cell in pyran and/or C. parvum induced host resistance to solid tumors: (1) Increased infiltration of tumors with histiocytes following systemic treatment with pyran;17 (2) activated peritoneal macrophages with tumoricidal activity have been recovered from the peritoneal cavity of normal or tumor bearing mice treated with pyran or C. parvum;17 (3) activated peritoneal macrophages mixed with tumor cells in vitro and transplanted into syngeneic recipients inhibited tumor growth; (4) trypan blue, an inhibitor of macrophage function, prevent C. parvum induced regression of methylcholanthrene tumors; and (5) direct intralesional injection of activated macrophages into the MCA 2182 tumor inhibited tumor growth and increased the MST.