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EVALUATION OF NARCOTIC AND NARCOTIC ANTAGONIST INTERACTIONS IN PRIMATES *
Author(s) -
Killam K. F.,
Brocco M. J.,
Robinson C. A.
Publication year - 1976
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1976.tb27943.x
Subject(s) - morphine , naltrexone , (+) naloxone , narcotic , diazepam , abstinence , narcotic antagonist , pharmacology , abstinence syndrome , methadone , antagonist , anesthesia , narcotic antagonists , withdrawal syndrome , methamphetamine , psychology , medicine , psychiatry , receptor
Multiple and single drug interactions were studied in morphine-dependent monkeys whose dependency was maintained by self-infusion. Naloxone, naltrexone, and cyclazocine precipitated abstinence syndrome which the animals generally controlled with increased morphine intake. Methadone and L-alpha-acetylmethadol (LAAM) initially reduced, then increased, the morphine intake. Multiple interactions were studied using ethanol, seconal, diazepam, amphetamine, and diphenylhydantoin.