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IMPLICATIONS OF IMMUNOLOGIC METHODS FOR MEASURING ANTIHEMOPHILIC FACTOR (FACTOR VIII) *
Author(s) -
Hoyer Leon W.,
Rick† Margaret E.
Publication year - 1975
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1975.tb53329.x
Subject(s) - annals , citation , medicine , impact factor , library science , new england , gerontology , classics , history , politics , political science , computer science , law
Recent immunologic studies have provided important new information about the nature of AHF deficiency diseases and the structure and synthesis of this protein. They provide, moreover, a considerably improved ability to identify the carrier state in hemophilia A. Additional progress may be possible in the identification of carriers and of hemophilic patients at risk of antibody formation, but it will require a different approach to these problems. While preliminary goals have been obtained by using antibodies that identify antigenic determinants shared by normal and nonfunctional AHF, further progress will require the capacity to identify differences between the normal protein and the nonfunctional AHF-like molecules in hemophilic plasma.