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SYNTHESIS OF FACTOR VIII ANTIGEN BY CULTURED HUMAN ENDOTHELIAL CELLS *
Author(s) -
Jaffe Eric A.
Publication year - 1975
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1975.tb53322.x
Subject(s) - citation , annals , library science , associate editor , medicine , classics , art , computer science
Endothelial cells have been isolated from freshly obtained human umbilical cords by collagenase digestion of the interior of the umbilical vein and grown in tissue culture. These cells have been identified by morphologic and immunologic criteria. It has been demonstrated that these cultured human endothelial cells synthesize and release factor VIII antigen but not factor VIII clot-promoting activity.