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IN VIVO BEHAVIOR OF A SINDBIS VIRUS MUTANT ISOLATED FROM PERSISTENTLY INFECTED AEDES AEGYPTI CELL CULTURES
Author(s) -
Peleg J.
Publication year - 1975
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1975.tb35102.x
Subject(s) - sindbis virus , virology , aedes aegypti , titer , virus , biology , mutant , in vivo , inoculation , vector (molecular biology) , strain (injury) , alphavirus , microbiology and biotechnology , immunology , larva , anatomy , ecology , rna , biochemistry , gene , recombinant dna
A mutant of the Sindbis virus SV-S was found to interfere with the regular course of infection by the wild strain of the virus SV-W in A. aegypti mosquitoes and in suckling mice. In mosquitoes, this result was manifested by a reduced titer of SV-W in the presence of SV-S and by a failure of the mosquitoes to transmit SV-W. In the brains of suckling mice, in the presence of SV-S, the growth of sc inoculated SV-W was suppressed, and as a result, the usually lethal course of infection by this virus was converted into a nonlethal one.