ASCORBIC ACID IN CHOLESTEROL AND BILE ACID METABOLISM | Zendy

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ASCORBIC ACID IN CHOLESTEROL AND BILE ACID METABOLISM

Author(s) -

Ginter Emil

Publication year - 1975

Publication title -

annals of the new york academy of sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.712

H-Index - 248

eISSN - 1749-6632

pISSN - 0077-8923

DOI - 10.1111/j.1749-6632.1975.tb29299.x

Subject(s) - ascorbic acid , citation , annals , library science , bile acid , medicine , computer science , chemistry , classics , history , food science

Latent chronic ascorbic acid deficiency provokes in guinea pigs a metabolic disorder in the liver, causing an impaired cholesterol transformation to its principal catabolic product, bile acids. This metabolic disorder induces hypercholesterolemia and accumulation of cholesterol in the liver and slows the release of cholesterol from the circulation. Ascorbic acid probably intervenes into the biosynthesis of bile acids at the stage of 7 alpha-hydroxylation of the cholesterol nucleus. High doses of ascorbic acid significantly stimulate cholesterol transformation to bile acids in guinea pigs and decrease plasma cholesterol concentration in humans.

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