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EFFECTS OF ASCORBIC ACID ON MICROSOMAL DRUG METABOLISM *
Author(s) -
Zani Vincent G.,
Sato Paul H.
Publication year - 1975
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1975.tb29272.x
Subject(s) - ascorbic acid , library science , medical school , citation , medicine , chemistry , computer science , medical education , food science
Studies from a number of laboratories have shown that vitamin C deficiency in guinea pigs results in decreased metabolism of a variety of pharmacological agents.'-'" In 1941, Richards et al.' found a prolonged sleeping time in scorbutic guinea pigs given pentobarbital compared with that of normal animals, and the administration of ascorbic acid reversed the effect. Axelrod et a1.j in 1954 reported up to a threefold increase in plasma half-life of such agents as acetanilid, aniline, or antipyrine in guinea pigs depleted of vitamin C that was attributed to lowered rates of metabolism. In addition, the increase in plasma half-life of these agents could be reversed in 4 to 6 days if the diet was replenished with ascorbic acid. Other laboratories 6, i have reported decreased oxidation of such agents as zoxazolamine, acetanilid, coumarin, diphenylhydramine, and meperidine in microsomes prepared from scorbutic guinea pigs. Our current knowledge of the hepatic electron transport system involving NADPH, cytochrome P-450 reductase, cytochrome P-450, and molecular oxygen required for the mixedfunction oxygenase-type drug hydroxylation reactions has allowed a more direct approach in studies on the effect of ascorbic acid in the oxidation of a variety of pharmacological agents.