Premium
INDUCTION OF T‐CELL DIFFERENTIATION IN VITRO BY THYMUS EPITHELIAL CELLS *
Author(s) -
Waksal Samuel D.,
Cohen Irun R.,
Waksal Harlan W.,
Wekerle Hartmut,
Pierre Ronald L. St.,
Feldman Michael
Publication year - 1975
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1975.tb29098.x
Subject(s) - annals , library science , medicine , classics , art , computer science
Thymus-reticular epithelial cells (TE-cells) were grown in a cell culture devoid of any lymphocytic elements. These cells were able to induce T-cell differentiation in spleen cells from T-dificient mice as expressed by con-A responsiveness and GvH reactivity. It was also shown that xenogeneic rat TE cells were as effective in the induction of T-cell differentiation in vitro as syngeneic TE cells. This system is therefore ideal for the study of T-cell development.