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RELATIONSHIP OF THE BIOSYNTHESIS OF α‐FETOPROTEIN, ALBUMIN, HEMOPEXIN, AND HAPTOGLOBIN TO THE GROWTH STATE OF FETAL RAT HEPATOCYTE CULTURES *
Author(s) -
Sell S.,
Leffert H. L.,
MullerEberhard U.,
Kida S.,
Skelly H.
Publication year - 1975
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1975.tb25401.x
Subject(s) - hemopexin , albumin , hepatocyte , chemistry , haptoglobin , fetus , in vitro , intracellular , medicine , biochemistry , endocrinology , serum albumin , biosynthesis , biology , pregnancy , heme , enzyme , genetics
AFP and albumin are produced by arginine-synthesizing fetal rat hepatocytes in vitro. AFP and hemopexin production are coupled to hepatocellular proliferation, whereas albumin and haptoglobin production are not. During the cell cycle, AFP is synthesized prior to S and released prior to M. AFP may play a role in regulation of hepatocellular growth through estradiol binding and modulation of the intracellular concentration of lipoprotein (VLDL).