Premium
EFFECT OF DIMETHYL SULFOXIDE AND HYDROGEN PEROXIDE ON TISSUE GAS TENSIONS *
Author(s) -
Myers M. Bert,
Donovan William
Publication year - 1975
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1975.tb25373.x
Subject(s) - dimethyl sulfoxide , hydrogen peroxide , chemistry , organic chemistry
Tissue gas levels were measured in experimental skin flaps in rabbits, rats, and pigs. Devascularization of the flaps led to a fall in PO2 and a rise in PCO2 levels. Application of DMSO to ischemic rabbit flaps led to a fall in PCO2, DMSO and H2O2 led to a rise in PO2, an effect that lasted up to 90 min. Neither drug had an effect on the gas levels of flaps in either rats or pigs.