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THE ROLE OF CONVECTION AND DIFFUSION ON PLATELET ADHESION AND AGGREGATION
Author(s) -
Leonard Edward F.,
Grabowski Eric F.,
Turitto Vincent T.
Publication year - 1972
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1972.tb16309.x
Subject(s) - platelet , diffusion , chemistry , thrombus , convection , platelet adhesion , rationalization (economics) , platelet adhesiveness , biophysics , mechanics , platelet aggregation , thermodynamics , medicine , physics , biology , epistemology , philosophy
Summary The reactions among clotting components, among platelets, and between these groups are complex biochemical phenomena that importantly affect thrombogenesis, but thrombogenesis is also affected by the physical phenomena of convection and diffusion, which, in turn, are importantly mediated by conditions of flow. The principles that govern convection and diffusion processes are generally well understood, but the significance of these processes in thrombogenesis is in only the early stages of demonstration. In this paper there have been considered the special effect of erythrocytes upon the diffusion of platelets in flowing blood; the measurement of the diffusion of platelets that had been rendered unreactive by a dispersion technique; measurement and rationalization of platelet adhesion to artificial surfaces; and a quantitative assessment of the role of platelet diffusion, activating substance diffusion, and platelet arrival on the growth of platelet aggregates. Further work is needed to explain the full role of convection and diffusion in platelet aggregation and thrombus formation, including a more detailed description of the platelet arrival process and the acquisition of more data concerning the time sequence of aggregate formation on surfaces of known geometry over which known flows are passing.