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ADHESION OF PLATELETS TO SUBENDOTHELIUM
Author(s) -
Baumgartner Hans R.,
Haudenschild Christian
Publication year - 1972
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1972.tb16285.x
Subject(s) - platelet , chemistry , elastin , biophysics , connective tissue , basement membrane , adhesion , endothelium , thrombogenicity , platelet adhesion , pathology , anatomy , immunology , biology , medicine , organic chemistry , endocrinology
Summary Endothelium provides the physiologic nonthrombogenic surface in vivo. Connective tissue components underneath the endothelial lining form the subendo‐thelium. The subendothelial surface appears far less thrombogenic than collagen fibers. Platelet adhesion to subendothelium as an entity is greatly enhanced by the presence of other blood cells, by an increase in the flow rate of the circulating blood, and by the presence of divalent cations. The affinity of platelets to different connective tissue components of the subendothelium varies markedly. When exposed to the same blood stream in a newly developed perfusion chamber, the affinity of platelets to the respective material decreases in the following order: collagen fibers, amorphous material (basement membrane), microfibrils, and elastin.