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INTERFERON PRODUCTION IN MICE BY CELL WALL MUTANTS OF SALMONELLA TYPHIMURIUM. III. ROLE OF LIPID MOIETY OF BACTERIAL LIPOPOLYSACCHARIDE IN INTERFERON PRODUCTION IN ANIMALS *
Author(s) -
Feingold David Sidney,
Youngner Julius S.,
Chen Joseph
Publication year - 1970
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1970.tb53415.x
Subject(s) - medicine , library science , microbiology and biotechnology , gerontology , biology , computer science
The interferon response elicited by Salmonella typhimurium mutants in mice is not dependent on the presence of a complete cell wall lipopolysaccharide. In fact, a mutant (G30/C21) which has lost all the polysaccharide side chains and sugars of the O antigen and contains only 2-keto-3-deoxyoctonate and lipid is indistinguishable in its interferon-stimulating ability from the wild type which possesses a complete O antigen with polysaccharide side chains.