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AN EXPERIMENTAL INVESTIGATION IN ANIMALS OF THE FUNCTIONAL AND MORPHOLOGIC EFFECTS OF SINGLE AND REPEATED EXPOSURES TO HIGH AND LOW CONCENTRATIONS OF CARBON MONOXIDE *
Author(s) -
Preziosi Thomas J.,
Lindenberg Richard,
Levy Donald,
Christenson Milton
Publication year - 1970
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1970.tb49800.x
Subject(s) - carbon monoxide , chemistry , environmental chemistry , biochemistry , catalysis
Dogs were acutely intermittently, or continuously exposed to 50 ppM--5% CO or to equivalent hypoxia. Of 38 dogs acutely exposed to CO or to hypoxia, 26 survived, but 15 of these showed distinct CNS changes, 10 showed right heart dilation, and 5 showed myocardial fiber degeneration. Most severe damage was in dogs surviving extended exposure resulting in COHb of 40 to 50%. Dogs exposed to 50 or 100 ppM CO, either intermittently or continuously for 6 weeks, showed signs of heart and brain pathology in a dose-related manner. These included dilation of the right heart, thinning of the myocardial wall, dilation of the brain ventricles and dilation of the posterior anterior horn. No histologic damage in brain was seen although the EKG was generally abnormal. Changes were similar in nature, but not in degree, to those seen with acute exposure.