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MORPHOLOGY OF LEUKOCYTIC HYPERGRANULATION IN BATTEN'S DISEASE *
Author(s) -
Donahue Sheila,
Watanabe Itaru,
Zeman Wolfgang
Publication year - 1969
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1969.tb50307.x
Subject(s) - granule (geology) , azurophilic granule , electron microscope , batten disease , granulation , chemistry , pathology , disease , biology , medicine , immunology , physics , inflammation , myeloperoxidase , paleontology , classical mechanics , optics
S ummary Histochemical and electron microscopic studies on the nature of the azurophilic hypergranulations of leukocytes in Batten's disease are reported. The exact nature of the phenomenon could not be elucidated, but it appears that the abnormal granulation is due to the prevalence of an intermediate granule in the polymorphonuclear cells. In electron microscopic preparations, the leukocyte granules from patients with Batten's disease are bounded by a unilaminar membrane, in contrast to the trilaminar membrane of the granules in controls. The possibility that this finding may represent a molecular lesion is discussed.