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STUDY OF BURN TOXINS
Author(s) -
Allgöwer M.,
Burri C.,
Cueni L.,
Engley F.,
Fleisch H.,
Gruber U. F.,
Harder F.,
Russell R. G. G.
Publication year - 1968
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1968.tb14732.x
Subject(s) - isolation (microbiology) , toxin , in vitro , biology , chemistry , immunology , microbiology and biotechnology , toxicology , biochemistry
S ummary A review has been presented of our studies on burn toxins from mouse skin. Sterile homogenates of mouse skin burned in vitro at 250°C rapidly induce neurological disturbances and eventually cause death when injected into normal mice. Such phenomena are not observed with homogenates of unburned skin. The toxic properties of burned mouse skin are apparently unrelated to bacterial factors and may be attributed to heat induced changes in components of normal skin. Preliminary studies on the isolation and characterization of the toxic material have been carried out. It is suggested that the toxic material contains protein and lipid components essential for its activity.