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VOLUME‐REGULATORY AND ENDOCRINE RELATIONSHIPS AFTER BLOOD LOSS IN MAN *
Author(s) -
Skillman John J.,
Moore Francis D.
Publication year - 1968
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1968.tb14716.x
Subject(s) - aldosterone , medicine , oncotic pressure , blood volume , endocrine system , endocrinology , homeostasis , plasma renin activity , renin–angiotensin system , albumin , plasma volume , secretion , blood pressure , hormone
S ummary 1. Transcapillary refilling after blood loss in man is a homeostatic adjustment which increases the blood volume. Although protein dilution occurs during this period, total plasma albumin rises, thus increasing the plasma oncotic pressure. 2. The renal‐circulatory adjustment to hemorrhage in man is accompanied by an increased aldosterone secretion and excretion. The evidence suggests that the renin‐angiotensin system plays a major role in aldosterone stimulation after hemorrhage, but does not exclude the possibility that other systems may be operating in addition to achieve aldosterone hypersecretion.