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GENETIC AND PHYLOGENETIC VARIATION IN THE DIFFERENT MOLECULAR FORMS OF MAMMALIAN ERYTHROCYTE CARBONIC ANHYDRASES *
Author(s) -
Tashian Richard E.,
Shreffler Donald C.,
Shows Thomas B.
Publication year - 1968
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1968.tb11878.x
Subject(s) - annals , medical genetics , public health , medical school , human services , library science , gerontology , medicine , genetics , history , biology , classics , political science , gene , medical education , pathology , law , computer science
Mammalian erythrocytes are known to possess either one or two molecular forms of carbonic anhydrase (c f . Tashian;’ Armstrong et al.;’ Duff and Coleman; Nyman and L i n d ~ k o g ; ~ and Edsall, preceding paper). In the present report, we will compare some genetic and chemical aspects of the presumed homologous forms of red cell carbonic anhydrase from various mammalian species. This type of comparative study gives us an unusual opportunity to analyze the changes that have occurred in two enzyme molecules which have, in all probability, originated by a process of gene duplication (cf. Nyman e ta l .”) , and have been “evolving” since that time in the same, or a similar, cytoplasmic environment. If this duplication occurred during the evolution of mammals, it might even be possible to locate its approximate phylogenetic position; and, by so doing, determine which of the two molecules represents the original form. The enzyme forms will be referred to in this paper as carbonic anhydrases I and I1 (CA I and CA 11) which are identical to the designations CA B and CA C, respectively, used by other investigator^."^ 3