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MECHANISM OF ANTIGEN RELEASE FROM CANINE KIDNEY HOMOTRANSPLANTS *
Author(s) -
Najarian John S.,
May James,
Cochrum Kent C.,
Baronberg Neiel,
Way Lawrence W.
Publication year - 1966
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1966.tb12841.x
Subject(s) - antigen , kidney , transplantation , antigenicity , kidney transplantation , medicine , immunology , chemistry , pathology
Summary Antigen release from canine renal homotransplants was demonstrated in the renal vein of the transplanted kidney. The antigen was carried from the transplanted kidney to the host as a soluble or particulate substance within the host plasma. The host leukocytes were not implicated in the transport system. Antigen could not be detected in the peripheral vein blood. Antigen could be demonstrated in the plasma leaving the transplanted kidney within 10 minutes after vascular anastomosis was completed. The release of antigen terminated 2 to 3 days after transplantation. The presence of donor antigen from renal homotransplantation may be related to the degree of kidney damage. C orticosteroid administration had no effect on the antigenicity of the transplanted kidneys.