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EFFECTS OF ACIDOSIS ON RESPIRATORY FUNCTION *
Author(s) -
Enson Yale
Publication year - 1965
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1965.tb14237.x
Subject(s) - ventilation (architecture) , acidosis , perfusion , respiratory acidosis , ventilation perfusion mismatch , respiratory system , oxygen , carbon dioxide , lung , medicine , chemistry , anesthesia , cardiology , perfusion scanning , physics , organic chemistry , thermodynamics
Summary and Conclusions The net effect of acidosis on the respiratory apparatus is an elevation of ventilation‐perfusion ratios. Alveolar ventilation is augmented; perfusion of the well‐ventilated portion of the lung is enhanced, while perfusion of the poorly ventilated space is diminished. A larger volume of oxygen is made available for release to the tissues. Carbon dioxide has been shown to have no effect on the pulmonary vasculature or on the oxyhemoglobin dissociation curve independent of the changes in hydrogen ion concentration it produces. Its role with respect to the control of ventilation has not yet clearly been defined.