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FURTHER STUDIES ON STERILITY PRODUCED IN MALE MICE BY DEUTERIUM OXIDE
Author(s) -
Hughes Ann M.,
Bennett Edward L.,
Calvin Melvin
Publication year - 1960
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1960.tb39108.x
Subject(s) - library science , national laboratory , chemistry , engineering physics , physics , computer science
Thirty percent D/sub 2/O in the drinking water of male Swiss mice produces sterility. Both a decrease in litter size and a decreased percentage of fertile matings were observed when treated males were mated with normal females. No increase in regressions was obtained. The development of mouse eggs in a female mated with a D/sub 2/O-treated male is generally abnormal; few multicelled eggs are obtained 2 to 2 1/2 days after copulation. It is suggested that changes in physical forces that bind macromolecules are produced by the substitution of deuterium for hydrogen. These changes may result in abnormal genetic material in developing sperm. (auth)