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CLINICAL PHARMACOLOGY OF BRETYLIUM TOSYLATE: PRELIMINARY OBSERVATIONS
Author(s) -
Conway James
Publication year - 1960
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1960.tb20087.x
Subject(s) - bretylium , annals , citation , medicine , library science , classics , adrenergic , computer science , history , receptor
The introduction of a new quaternary ammonium compound, bretylium tosylate,' ,* which selectively blocks transmission in postganglionic sympathetic nerve fibers, may be an important advance in the treatment of hypertension and peripheral vascular diseases. Of equal interest is the opportunity it provides for the evaluation of the role of the sympathetic nervous system in the pathogenesis of these diseases. An attempt has been made, therefore, to study the ability of bretylium to block sympathetically mediated reflexes in man, and to determine the changes it produces in the circulation. The effect on the blood pressure after parenteral and oral administration has also been assessed.