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PRODUCTION OF NEOPLASMS BY INJECTION OF FRACTIONS OF MAMMALIAN NEOPLASMS
Author(s) -
Stasney Joseph,
Cantarow A.,
Paschkis Karl E.
Publication year - 1952
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1111/j.1749-6632.1952.tb39987.x
Subject(s) - citation , cancer , library science , medicine , gerontology , family medicine , computer science
Summary Lymphosarcomas developed in rats at the site of subcutaneous and intramedullary injection of chromatin and mitochondria fractions of the Murphy rat lymphosarcoma. Leukemia occurred in a high percentage of animals which developed local tumors following subcutaneous injection of lymphosarcoma cell fractions. Hepatomas developed in two rats at the site of intrahepatic injection of the mitochondria fraction of AAF-induced rat hepatomas. This fraction may have been contaminated with chromation fragments. Direct proof of the absence of intact cells in these fractions is impossible, but data presented seem to indicate that such contamination is highly improbable.