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Coenzyme Q10 in combination with steroid therapy for treatment of sudden sensorineural hearing loss: a controlled prospective study
Author(s) -
Ahn J.H.,
Yoo M.H.,
Lee H.J.,
Chung J.W.,
Yoon T.H.
Publication year - 2010
Publication title -
clinical otolaryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.914
H-Index - 68
eISSN - 1749-4486
pISSN - 1749-4478
DOI - 10.1111/j.1749-4486.2010.02201.x
Subject(s) - medicine , coenzyme q10 , pure tone audiometry , audiology , prospective cohort study , sensorineural hearing loss , audiometry , hearing loss
Clin. Otolaryngol. 2010, 35 , 486–489 Objective: To evaluate the therapeutic efficacy of coenzyme Q10 added to systemic steroid in patients with idiopathic sudden sensorineural hearing loss. Design: A controlled prospective study. Setting: Asan medical center, University of Ulsan College of Medicine. Participants: Between August 2007 and October 2008, the first 60 patients diagnosed with sudden sensorineural hearing loss were managed with systemic steroid treatment for 2 weeks including 5‐day hospitalisation. And the second 60 patients were managed with coenzyme Q10 for 2 weeks added to previous management. Main outcome measures: We evaluated auditory function by pure tone audiometry and speech discrimination score. Auditory evaluations were performed before and 3 months after treatment using Siegel’s criteria. The degree of improvement in four‐tone average hearing and speech discrimination score was calculated from the results before and after treatment. Results: The total hearing improvement rate after the treatment was 75.0% (90/120 patients) in this study. Although 47 patients (78.3%) of coenzyme Q10 group showed better hearing improvement than 43 patients (71.7%) of control group, there was no significant difference. However, the coenzyme Q10 group showed significantly higher improvement in speech discrimination score. Conclusion: From this study, we suggest that coenzyme Q10 may have beneficial effects in the treatment of sudden sensorineural hearing loss.