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Treatment and prognostic factors of papillary thyroid microcarcinoma
Author(s) -
Giordano D.,
Gradoni P.,
Oretti G.,
Molina E.,
Ferri T.
Publication year - 2010
Publication title -
clinical otolaryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.914
H-Index - 68
eISSN - 1749-4486
pISSN - 1749-4478
DOI - 10.1111/j.1749-4486.2010.02085.x
Subject(s) - medicine , otorhinolaryngology , univariate analysis , retrospective cohort study , incidence (geometry) , multivariate analysis , tertiary referral hospital , disease , thyroid , surgery , gastroenterology , physics , optics
Clin. Otolaryngol. 2010, 35 , 118–124 Objective: To discuss the prognostic factors and outcomes of treatment in patients diagnosed with papillary thyroid microcarcinoma. Design: Retrospective observational case review. Setting: Department of Otorhinolaryngology of the tertiary referral teaching hospital of Parma. Participants: Ninety‐seven patients diagnosed with PTMC and surgically treated between January 1998 and December 2007. Main outcome measures: Clinical and histopathological characteristics of the study group were identified and statistically analysed. Results: No cancer‐related deaths were registered. Incidence of recurrent disease was 9% after a 43 month mean follow‐up (range 12–120). Univariate analysis detected that metastases in neck lymph nodes at diagnosis ( p = 0.025), a tumour >5 mm in size ( p = 0.011), the presence of bilateral tumoural foci ( p = 0.007), the presence of capsular invasion ( p = 0.001), and the presence of vascular invasion ( p = 0.004) were related to recurrent disease. On multivariate analysis, the presence of bilateral tumoural foci ( p = 0.030), and the presence of capsular invasion ( p = 0.005) were significantly related to tumour recurrence. Conclusion: The prognosis for patients with papillary thyroid microcarcinoma in this series was excellent, with a 100% survival rate and minimal surgical‐related morbidity. Nevertheless, approximately 10% of patients developed recurrent disease; aggressive treatment may be justified depending on the presence or absence of prognostic risk factors.