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Carcinocythaemia (carcinoma cell leukaemia) in a dog: an acute leukaemia‐like picture due to metastatic carcinoma
Author(s) -
A M.,
M F.,
A G.,
B B.,
B W.
Publication year - 2012
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.2012.01237.x
Subject(s) - medicine , pathology , lethargy , bone marrow , population , carcinoma , immunohistochemistry , environmental health
An eight‐year‐old entire female boxer was presented with a two‐week history of anorexia and lethargy and two‐day history of unilateral left epistaxis. Clinical findings and laboratory test results suggested disseminated intravascular coagulation. On blood smear evaluation, occasional large epithelioid‐like unclassified cells were detected. Occasionally these cells were organised in small clusters. Bone marrow examination revealed a marked infiltration by a malignant population of the same epithelioid‐like cells. The dog was euthanased because of the guarded prognosis. Following histology and immunohistochemistry, a widespread undifferentiated carcinoma of unknown primary origin was diagnosed. To the authors’ knowledge, this is the first case of carcinoma cell leukaemia reported in a dog. Carcinoma cell leukaemia is a rare oncological condition previously described in humans, characterised by non‐haematopoietic neoplastic cells in peripheral blood.