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Membranoproliferative glomerulonephritis possibly associated with over‐vaccination in a cocker spaniel
Author(s) -
Ortloff A.,
Morán G.,
Olavarría A.,
Folch H.
Publication year - 2010
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.2010.00978.x
Subject(s) - medicine , membranoproliferative glomerulonephritis , vaccination , dermatology , immunology , glomerulonephritis , kidney
Membranoproliferative glomerulonephritis was observed in a seven‐month‐old male cocker spaniel dog. The clinical, microbiological, biochemical, radiographic and ultrasonographic examinations ruled out neoplasia, congenital disease and infectious disease. The anamnesis revealed that the owner had vaccinated the dog seven times, one vaccination per month, without veterinarian supervision. In both kidneys, severe thickening of the glomerular capillary walls was observed. Electron microscope examination revealed a large number of electron‐dense deposits that were primarily in the glomerular subendothelial spaces and the basal membrane, which is compatible with antigen‐antibody complexes. The immunohistochemical examination revealed that the antigen present in the glomeruli corresponded with the antigen present in the vaccine. We report a type III hypersensitivity nephropathy in a young dog, which was possibly caused by over‐vaccination.