Premium
Haemophilia A (factor VIII deficiency) in a litter of Weimaraners
Author(s) -
Dunning M. D.,
Averis G. F.,
Pattinson H.,
Targett M.,
Cade S.,
Herrtage M. E.
Publication year - 2009
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.2009.00727.x
Subject(s) - medicine , haemophilia , haemophilia a , litter , haemophilia b , pediatrics , mutation , genetics , gene , biology , agronomy
Inherited coagulopathies are reported in a number of dog breeds. However, to date, there is no report of Weimaraners suffering factor VIII deficiency (haemophilia A). We report the discovery of haemophilia A in both males from a single litter of Weimaraners. Haemophilia A in human beings often results from a de novo stochastic mutation. We found no evidence using currently available screening tests of haemophilia A in relatives as far back as three generations making a stochastic mutation possible in this litter.