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Use of intralesional oestradiol concentration to identify a functional pulmonary metastasis of canine sertoli cell tumour
Author(s) -
Gopinath D.,
Draffan D.,
Philbey A. W.,
Bell R.
Publication year - 2009
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.2008.00671.x
Subject(s) - medicine , metastasis , pathology , sertoli cell , urology , castration , hormone , cancer , spermatogenesis
A seven‐year‐old, 31 kg male neutered Labrador was investigated for signs of feminisation syndrome and prostatic disease four years after castration and removal of a testicular sertoli cell tumour (SCT). Investigations revealed an elevated serum oestradiol‐17β concentration, a pulmonary mass containing fluid high in oestradiol‐17β and cystic changes in the prostate gland. The pulmonary mass was surgically excised and histologically confirmed to be a SCT metastasis. To the authors’ knowledge, this is the first reported case of a proven functional extranodal SCT metastasis and the first to be diagnosed by oestradiol‐17β measurement of intralesional fluid.