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Efficacy and safety of cefovecin for the treatment of urinary tract infections in cats
Author(s) -
Passmore C. A.,
Sherington J.,
Stegemann M. R.
Publication year - 2008
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.2008.00545.x
Subject(s) - cats , medicine , urinary system , urine , adverse effect , gastroenterology
O bjectives :To determine the efficacy and safety of cefovecin (Convenia ® ; Pfizer Animal Health) in the treatment of urinary tract infections in cats.M ethod :A multi‐centre, masked, randomised study was conducted in cats presenting with clinical signs indicative of urinary tract infections. Cephalexin (Rilexine ® ; Virbac) administered orally twice daily at 15 mg/kg bodyweight for 14 days was compared with a single subcutaneous injection of cefovecin in cats. The primary efficacy parameter assessed was bacterial elimination of the pretreatment uropathogen.R esults :Four hundred and thirty‐four cats were screened for urinary tract infections. One hundred and eighty‐five cats were treated with either cefovecin (n=124) or cephalexin (n=61). Ninety‐seven cats (22·2 per cent) had confirmed bacteriuria and 82 cats were included in efficacy analysis. Escherichia coli was eliminated in 76·7 per cent (23 of 30) of cefovecin‐treated cats compared with 62·5 per cent (10 of 16) of cephalexin‐treated cats. Cefovecin demonstrated statistical non‐inferiority compared with cephalexin for bacterial elimination. There were no suspected adverse drug reactions attributable to treatment with cefovecin or cephalexin.C linical S ignificance :Cefovecin was demonstrated to be an effective and safe treatment for urinary tract infections.