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Hypertrophic osteopathy associated with infective endocarditis in an adult boxer dog
Author(s) -
Dunn M. E.,
Blond L.,
Letard D.,
DiFruscia R.
Publication year - 2007
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.2006.00159.x
Subject(s) - medicine , infective endocarditis , lethargy , lameness , intracardiac injection , microfilaria , osteopathy , endocarditis , pathology , surgery , immunology , alternative medicine , helminths , filariasis
A 20‐month‐old, entire male boxer dog was presented with lethargy and intermittent shifting limb lameness. Diagnostic tests revealed aortic valve vegetations suggestive of infective endocarditis causing severe aortic outflow obstruction, and hypertrophic osteopathy of all four limbs. The dog was treated symptomatically and euthanased four days later. The association of infective endocarditis and hypertrophic osteopathy has been poorly documented in the veterinary literature. The pathogenesis of hypertrophic osteopathy is unknown; however, four theories have been put forth to explain this disease: pulmonary shunting, vagal nerve stimulation, humoral substances produced by neoplastic cells and megakaryocyte/platelet clump hypothesis.