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Combined clotrimazole irrigation and depot therapy for canine nasal aspergillosis
Author(s) -
Sissener T. R.,
Bacon N. J.,
Friend E.,
Anderson D. M.,
White R. A. S.
Publication year - 2006
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.2006.00017.x
Subject(s) - medicine , clotrimazole , aspergillosis , surgery , flushing , sinus (botany) , anesthesia , antifungal , dermatology , botany , immunology , biology , genus , endocrinology
O bjectives :To evaluate the effect of short duration 1 per cent clotrimazole flush when combined with 1 per cent clotrimazole cream instilled into the frontal sinuses for the treatment of nasal aspergillosis in 14 dogs.M ethods :Fourteen dogs with clinical, radiological, serological and rhinoscopic findings consistent with nasal aspergillosis were treated by frontal sinus trephination and a short, five‐minute flushing of 1 per cent topical clotrimazole solution followed by a 1 per cent clotrimazole cream instilled as a depot agent.R esults :Twelve of the 14 dogs (86 per cent) responded well to treatment and either had no clinical signs after treatment or had signs consistent with mild rhinitis during a minimum follow‐up period of six months. Only one dog required multiple treatments. Treatment was well tolerated by all patients, with minimal complications.C linical S ignificance :This treatment compares favourably to previously published data using one‐hour topical clotrimazole or enilconazole flushing treatment protocols. The treatment technique significantly reduced treatment time under anaesthesia.