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Treatment of insulinoma in a springer spaniel with streptozotocin
Author(s) -
Bell R.,
Mooney C. T.,
Mansfield C. S.,
Jones B. R.
Publication year - 2005
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.2005.tb00318.x
Subject(s) - medicine , insulinoma , streptozotocin , diuresis , surgery , diabetes mellitus , anesthesia , endocrinology , insulin , kidney
An eight‐year‐old, female springer spaniel was treated for metastatic insulinoma with a single intravenous dose of 500 mg/m2 streptozotocin (SZN), and pre‐and post‐treatment diuresis. A tapering dose of corticosteroids was also administered over a 28‐day period. SZN and corticosteroid administration resulted in resolution of hypoglycaemia and subsequent development of diabetes mellitus. Further metastases caused cervical spinal pain and the dog was euthanased 118 days after SZN administration. SZN can be safely used for the treatment of canine insulinoma, but, when compared with other published cases, a marked variation in clinical response to this drug exists and further study is warranted.