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Adrenal necrosis in a dog receiving trilostane for the treatment of hyperadrenocorticism
Author(s) -
Chapman P. S.,
Kelly D. F.,
Archer J.,
Brockman D. J.,
Neiger R.
Publication year - 2004
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.2004.tb00241.x
Subject(s) - medicine , exploratory laparotomy , fludrocortisone , prednisolone , adrenal gland , necrosis , adrenal insufficiency , biopsy , laparotomy , surgery , hydrocortisone
Clinical and biochemical changes suggestive of hypoadrenocorticism were observed in a 10‐year‐old male neutered Staffordshire bull terrier shortly after beginning therapy with trilostane for the treatment of hyperadrenocorticism. The dog's condition was stabilised with intravenous fluids, fludrocortisone and prednisolone. An exploratory laparotomy and excisional biopsy of the left adrenal gland were performed. Histopathological analysis showed adrenal cortical necrosis with reactive inflammation and fibrosis. Trilostane is a reversible inhibitor of steroid synthesis and this complication has not been reported previously. Clinicians should be aware that trilostane therapy may result in adrenal necrosis but that prompt treatment might correct a life‐threatening situation.