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Risk factor analysis and relative supersaturation as tools for identifying calcium oxalate stone‐forming dogs
Author(s) -
Stevenson A. E.,
Robertson W. G.,
Markwell P.
Publication year - 2003
Publication title -
journal of small animal practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.7
H-Index - 67
eISSN - 1748-5827
pISSN - 0022-4510
DOI - 10.1111/j.1748-5827.2003.tb00109.x
Subject(s) - calcium oxalate , medicine , relative risk , uric acid , urinary system , breed , urine , oxalate , zoology , confidence interval , biology , chemistry , organic chemistry
Twenty‐four hour urine samples were collected from 17 calcium oxalate (CaOx) stone‐forming (SF) dogs and 17 normal (N), age‐, breed‐ and sex‐matched dogs. Urinary CaOx relative supersaturation (RSS) was calculated and found to be significantly higher in the SF group than the N group. RSS measurement is not readily applicable to veterinary practice; thus, alternatives were explored. Discriminant analysis failed to identify key factors differentiating most SF from N dogs. Urinary calcium, oxalate and uric acid, which differed between the SF and N animals, were combined into a measure of relative probability of CaOx stone formation (P SF ) to establish whether this approach could be used to assess the risk of CaOx stone formation in dogs. Although there was good correlation between the techniques, RSS more clearly discriminated between SF and N dogs. These data suggest that neither PSF nor discriminant analysis is preferable to RSS for assessing the risk of CaOx stone formation in dogs.